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Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS).
Mandrioli, Jessica; Crippa, Valeria; Cereda, Cristina; Bonetto, Valentina; Zucchi, Elisabetta; Gessani, Annalisa; Ceroni, Mauro; Chio, Adriano; D'Amico, Roberto; Monsurrò, Maria Rosaria; Riva, Nilo; Sabatelli, Mario; Silani, Vincenzo; Simone, Isabella Laura; Sorarù, Gianni; Provenzani, Alessandro; D'Agostino, Vito Giuseppe; Carra, Serena; Poletti, Angelo.
Affiliation
  • Mandrioli J; Department of Neurosciences, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Crippa V; Dipartimento di Scienze Farmacologiche e Biomolecolari, Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano, Italy.
  • Cereda C; Genomics and Post-Genomics Center, IRCCS Mondino Foundation, Pavia, Italy.
  • Bonetto V; Laboratory of Translational Biomarkers, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
  • Zucchi E; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gessani A; Department of Neurosciences, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Ceroni M; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Chio A; Department of General Neurology, Rare Diseases Unit, IRCCS Mondino Foundation, Pavia, Italy.
  • D'Amico R; "Rita Levi Montalcini" Departmentof Neurosciences, ALS Centre, University of Turin and Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
  • Monsurrò MR; Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
  • Riva N; Dipartimento ad attività integratedi Medicina Interna e Specialistica, Azienda Ospedaliero Universitaria "L. Vanvitelli", Napoli, Italy.
  • Sabatelli M; Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
  • Silani V; Neuromuscular Omni Centre (NEMO), Fondazione Serena Onlus, Policlinico A. Gemelli IRCCS, Roma, Italy.
  • Simone IL; Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma, Italy.
  • Sorarù G; UOC di Neurologia, Dipartimento di Scienze dell'invecchiamento, Neurologiche, ortopediche e della testa collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
  • Provenzani A; Department of Neurology-Stroke Unitand Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
  • D'Agostino VG; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Milano, Italy.
  • Carra S; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy.
  • Poletti A; Department of Neurosciences, University of Padua, Padua, Italy.
BMJ Open ; 9(5): e028486, 2019 05 30.
Article in En | MEDLINE | ID: mdl-31152038
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Full text: 1 Database: MEDLINE Main subject: Autophagy / Colchicine / Neuroprotective Agents / HSP20 Heat-Shock Proteins / Proteostasis / Amyotrophic Lateral Sclerosis Type of study: Clinical_trials / Guideline Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: BMJ Open Year: 2019 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Autophagy / Colchicine / Neuroprotective Agents / HSP20 Heat-Shock Proteins / Proteostasis / Amyotrophic Lateral Sclerosis Type of study: Clinical_trials / Guideline Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: BMJ Open Year: 2019 Type: Article Affiliation country: Italy