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Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts.
Lam, Hung-Ming; Nguyen, Holly M; Labrecque, Mark P; Brown, Lisha G; Coleman, Ilsa M; Gulati, Roman; Lakely, Bryce; Sondheim, Daniel; Chatterjee, Payel; Marck, Brett T; Matsumoto, Alvin M; Mostaghel, Elahe A; Schweizer, Michael T; Nelson, Peter S; Corey, Eva.
Affiliation
  • Lam HM; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA; Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
  • Nguyen HM; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
  • Labrecque MP; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
  • Brown LG; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
  • Coleman IM; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Gulati R; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Lakely B; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
  • Sondheim D; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA.
  • Chatterjee P; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Marck BT; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
  • Matsumoto AM; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, W
  • Mostaghel EA; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA.
  • Schweizer MT; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Nelson PS; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA.
  • Corey E; Department of Urology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: ecorey@uw.edu.
Eur Urol ; 77(2): 144-155, 2020 02.
Article in En | MEDLINE | ID: mdl-31227306
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Full text: 1 Database: MEDLINE Main subject: Testosterone / Prostatic Neoplasms, Castration-Resistant Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Eur Urol Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Testosterone / Prostatic Neoplasms, Castration-Resistant Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Eur Urol Year: 2020 Type: Article Affiliation country: China