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Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors.
Lai, Meng-Zhen; Song, Pei-Ran; Dou, Dou; Diao, Yan-Yan; Tong, Lin-Jiang; Zhang, Tao; Xie, Hua; Li, Hong-Lin; Ding, Jian.
Affiliation
  • Lai MZ; School of Pharmacy, Nanchang University, Nanchang, 330006, China.
  • Song PR; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Dou D; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Diao YY; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Tong LJ; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang T; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
  • Xie H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
  • Li HL; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Ding J; University of Chinese Academy of Sciences, Beijing, 100049, China.
Acta Pharmacol Sin ; 41(3): 415-422, 2020 Mar.
Article in En | MEDLINE | ID: mdl-31316181
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Protein Kinase Inhibitors / Drug Discovery / Agammaglobulinaemia Tyrosine Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Protein Kinase Inhibitors / Drug Discovery / Agammaglobulinaemia Tyrosine Kinase / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: China