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Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity.
Sundberg, John P; Pratt, C Herbert; Silva, Kathleen A; Kennedy, Victoria E; Qin, Wenning; Stearns, Timothy M; Frost, Jacqueline; Sundberg, Beth A; Bowcock, Anne M.
Affiliation
  • Sundberg JP; The Jackson Laboratory, Bar Harbor, ME, USA. Electronic address: john.sundberg@jax.org.
  • Pratt CH; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Silva KA; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Kennedy VE; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Qin W; eGenesis, Cambridge, MA, USA.
  • Stearns TM; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Frost J; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sundberg BA; The Jackson Laboratory, Bar Harbor, ME, USA.
  • Bowcock AM; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Departments of Dermatology, Genetics & Genome Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: anne.bowcock@mssm.edu.
Exp Mol Pathol ; 110: 104286, 2019 10.
Article in En | MEDLINE | ID: mdl-31323190
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Full text: 1 Database: MEDLINE Main subject: Psoriasis / Skin Diseases / Guanylate Kinases / CARD Signaling Adaptor Proteins / Genes, Modifier / Gain of Function Mutation / Guanylate Cyclase / Inflammation / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Exp Mol Pathol Year: 2019 Type: Article
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Psoriasis / Skin Diseases / Guanylate Kinases / CARD Signaling Adaptor Proteins / Genes, Modifier / Gain of Function Mutation / Guanylate Cyclase / Inflammation / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Exp Mol Pathol Year: 2019 Type: Article