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Styrenes from the Seeds of Atalantia monophylla.
Sribuhom, Thurdpong; Thummanant, Yutthapong; Phusrisom, Suphanthip; Kukongviriyapan, Veerapol; Tontapha, Sarawut; Amornkitbamrung, Vittaya; Yenjai, Chavi.
Affiliation
  • Sribuhom T; Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Thummanant Y; Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Phusrisom S; Department of Pharmacology, Faculty of Medicine , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Kukongviriyapan V; Department of Pharmacology, Faculty of Medicine , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Tontapha S; Integrated Nanotechnology Research Centre, Department of Physics, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Amornkitbamrung V; Integrated Nanotechnology Research Centre, Department of Physics, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
  • Yenjai C; Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science , Khon Kaen University , Khon Kaen 40002 , Thailand.
J Nat Prod ; 82(8): 2246-2251, 2019 08 23.
Article in En | MEDLINE | ID: mdl-31390210
ABSTRACT
Four new dimeric styrenes, 1-4, were isolated from an EtOAc crude extract of the seeds of Atalantia monophylla. The biosynthetic pathway of 1 is proposed to involve a [2 + 2] cycloaddition, while 2-4 may be generated via a polar mechanism with a carbocation as the key intermediate. The structures of 1-4 were defined from spectroscopic analysis; experimental and calculated ECD spectra were used to characterize their absolute configurations. When tested against two different cancer cell lines, 1-4 were not determined to be cytotoxic (IC50 > 10 µM).
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Full text: 1 Database: MEDLINE Main subject: Seeds / Styrenes / Rutaceae Limits: Humans Language: En Journal: J Nat Prod Year: 2019 Type: Article Affiliation country: Thailand
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Full text: 1 Database: MEDLINE Main subject: Seeds / Styrenes / Rutaceae Limits: Humans Language: En Journal: J Nat Prod Year: 2019 Type: Article Affiliation country: Thailand