Styrenes from the Seeds of Atalantia monophylla.
J Nat Prod
; 82(8): 2246-2251, 2019 08 23.
Article
in En
| MEDLINE
| ID: mdl-31390210
ABSTRACT
Four new dimeric styrenes, 1-4, were isolated from an EtOAc crude extract of the seeds of Atalantia monophylla. The biosynthetic pathway of 1 is proposed to involve a [2 + 2] cycloaddition, while 2-4 may be generated via a polar mechanism with a carbocation as the key intermediate. The structures of 1-4 were defined from spectroscopic analysis; experimental and calculated ECD spectra were used to characterize their absolute configurations. When tested against two different cancer cell lines, 1-4 were not determined to be cytotoxic (IC50 > 10 µM).
Full text:
1
Database:
MEDLINE
Main subject:
Seeds
/
Styrenes
/
Rutaceae
Limits:
Humans
Language:
En
Journal:
J Nat Prod
Year:
2019
Type:
Article
Affiliation country:
Thailand