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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.
van der Lee, Sven J; Knol, Maria J; Chauhan, Ganesh; Satizabal, Claudia L; Smith, Albert Vernon; Hofer, Edith; Bis, Joshua C; Hibar, Derrek P; Hilal, Saima; van den Akker, Erik B; Arfanakis, Konstantinos; Bernard, Manon; Yanek, Lisa R; Amin, Najaf; Crivello, Fabrice; Cheung, Josh W; Harris, Tamara B; Saba, Yasaman; Lopez, Oscar L; Li, Shuo; van der Grond, Jeroen; Yu, Lei; Paus, Tomas; Roshchupkin, Gennady V; Amouyel, Philippe; Jahanshad, Neda; Taylor, Kent D; Yang, Qiong; Mathias, Rasika A; Boehringer, Stefan; Mazoyer, Bernard; Rice, Ken; Cheng, Ching Yu; Maillard, Pauline; van Heemst, Diana; Wong, Tien Yin; Niessen, Wiro J; Beiser, Alexa S; Beekman, Marian; Zhao, Wanting; Nyquist, Paul A; Chen, Christopher; Launer, Lenore J; Psaty, Bruce M; Ikram, M Kamran; Vernooij, Meike W; Schmidt, Helena; Pausova, Zdenka; Becker, Diane M; De Jager, Philip L.
Affiliation
  • van der Lee SJ; 1Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Knol MJ; 1Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Chauhan G; 2University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, 33000 Bordeaux, France.
  • Satizabal CL; 3Centre for Brain Research, Indian Institute of Science, Bangalore, 560012 India.
  • Smith AV; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX 78229 USA.
  • Hofer E; 5Boston University School of Medicine and the Framingham Heart Study, Boston, MA 02118 USA.
  • Bis JC; 6Icelandic Heart Association, 201 Kopavogur, Iceland.
  • Hibar DP; 7Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
  • Hilal S; 8Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036 Austria.
  • van den Akker EB; 9Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036 Austria.
  • Arfanakis K; 10Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101 USA.
  • Bernard M; 11Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90292 USA.
  • Yanek LR; 1Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Amin N; 12Department of Pharmacology, National University of Singapore, Singapore, 117600 Singapore.
  • Crivello F; 13Memory, Aging and Cognition Center, National University Health System, Singapore, 119228 Singapore.
  • Cheung JW; 14Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Harris TB; 15Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZA the Netherlands.
  • Saba Y; 16Pattern Recognition & Bioinformatics, Delft University of Technology, Delft, 2628XE the Netherlands.
  • Lopez OL; 17Department of Biomedical Data Sciences, Statistical Genetics, Leiden University Medical Center, Leiden, 2333ZA the Netherlands.
  • Li S; 18Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616 USA.
  • van der Grond J; 19Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612 USA.
  • Yu L; 20The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8 ON Canada.
  • Paus T; 21GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA.
  • Roshchupkin GV; 1Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Amouyel P; 22Neurofunctional Imaging Group - Neurodegenerative Diseases Institute, UMR 5293, Team 5 - CEA - CNRS - Bordeaux University, Bordeaux, 33076 France.
  • Jahanshad N; 11Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90292 USA.
  • Taylor KD; 23Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892 USA.
  • Yang Q; 24Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
  • Mathias RA; 25Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260 USA.
  • Boehringer S; 26Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118 USA.
  • Mazoyer B; 27Department of Radiology, Leiden University Medical Center, Leiden, 2333ZA the Netherlands.
  • Rice K; 19Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612 USA.
  • Cheng CY; 28Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, M4G 1R8 Canada.
  • Maillard P; 29Departments of Psychology and Psychiatry, University of Toronto, Toronto, M5S 1A1 Canada.
  • van Heemst D; 1Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Wong TY; 14Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Niessen WJ; 30Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
  • Beiser AS; Univ. Lille, Inserm, Centre Hosp. Univ Lille, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related, 59000 Lille, France.
  • Beekman M; 11Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90292 USA.
  • Zhao W; 32Institute for Translational Genomics and Population Sciences, Department of Pediatrics at LABioMed-Harbor-UCLA Medical Center, Torrance, CA 90502 USA.
  • Nyquist PA; 26Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118 USA.
  • Chen C; 21GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA.
  • Launer LJ; 17Department of Biomedical Data Sciences, Statistical Genetics, Leiden University Medical Center, Leiden, 2333ZA the Netherlands.
  • Psaty BM; 22Neurofunctional Imaging Group - Neurodegenerative Diseases Institute, UMR 5293, Team 5 - CEA - CNRS - Bordeaux University, Bordeaux, 33076 France.
  • Ikram MK; 33Department of Biostatistics, University of Washington, Seattle, WA 98195 USA.
  • Vernooij MW; 34Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 169857 Singapore.
  • Schmidt H; 35Imaging of Dementia and Aging (IDeA) Laboratory, University of California-Davis, Davis, CA 95817 USA.
  • Pausova Z; 36Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA the Netherlands.
  • Becker DM; 34Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 169857 Singapore.
  • De Jager PL; 30Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, 3015CN the Netherlands.
Commun Biol ; 2: 285, 2019.
Article in En | MEDLINE | ID: mdl-31396565
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.
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Full text: 1 Database: MEDLINE Main subject: Parietal Lobe / Temporal Lobe / Genetic Variation / Genetic Loci / Frontal Lobe / Occipital Lobe Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Commun Biol Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Parietal Lobe / Temporal Lobe / Genetic Variation / Genetic Loci / Frontal Lobe / Occipital Lobe Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: Commun Biol Year: 2019 Type: Article