Mannose-Binding Lectin Levels in Late-Onset Sepsis in Preterm Infants: Results from a Prospective Study in a Tertiary Care Center.
Fetal Pediatr Pathol
; 39(5): 363-372, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-31411530
ABSTRACT
Introduction:
This study aimed to determine the association between serum mannose-binding lectin (MBL) levels, gene polymorphisms and late-onset sepsis (LOS) in preterm infants.Methods:
Infants with <37 gestational weeks were categorized into two groups according to the presence of LOS during their hospitalization. An MBL level <700 ng/ml was defined as deficiency, <400 ng/ml as severe deficiency. Codon 54 and 57 polymorphisms of MBL2 gene were analyzed.Results:
Overall, 153 preterm infants were included. MBL deficiency was found to be more common in the LOS group (p = 0.02). The rate of Gram-negative sepsis was higher in MBL2 variant-type (p = 0.01). In the logistic regression analysis, MBL levels <700 ng/ml were found to have a significant effect on LOS development (odds ratio 2.692, 95% confidence interval 1.196-5.8, p = 0.02).Conclusions:
MBL deficiency is an important risk factor for the development of LOS. Furthermore, there is an association between MBL2 gene polymorphism and Gram-negative sepsis.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sepsis
/
Mannose-Binding Lectin
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Fetal Pediatr Pathol
Journal subject:
PATOLOGIA
/
PEDIATRIA
Year:
2020
Type:
Article
Affiliation country:
Turkey