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Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment.
Riou, Catherine; Jhilmeet, Nishtha; Rangaka, Molebogeng X; Wilkinson, Robert J; Wilkinson, Katalin A.
Affiliation
  • Riou C; Wellcome Center for Infectious Disease Research in Africa, University of Cape Town, South Africa.
  • Jhilmeet N; Division of Medical Virology, Department of Pathology, University of Cape Town, South Africa.
  • Rangaka MX; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
  • Wilkinson RJ; Wellcome Center for Infectious Disease Research in Africa, University of Cape Town, South Africa.
  • Wilkinson KA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
J Infect Dis ; 221(1): 162-167, 2020 01 01.
Article in En | MEDLINE | ID: mdl-31419285
The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.
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Full text: 1 Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / HIV Infections / Anti-HIV Agents / Latent Tuberculosis / Mycobacterium tuberculosis Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: South Africa

Full text: 1 Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / HIV Infections / Anti-HIV Agents / Latent Tuberculosis / Mycobacterium tuberculosis Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: J Infect Dis Year: 2020 Type: Article Affiliation country: South Africa