Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment.
J Infect Dis
; 221(1): 162-167, 2020 01 01.
Article
in En
| MEDLINE
| ID: mdl-31419285
The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
CD4-Positive T-Lymphocytes
/
HIV Infections
/
Anti-HIV Agents
/
Latent Tuberculosis
/
Mycobacterium tuberculosis
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Infect Dis
Year:
2020
Type:
Article
Affiliation country:
South Africa