Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.

Zhang, Suyang; Tischer, Thomas; Barford, David

Zhang, Suyang; Tischer, Thomas; Barford, David.

Affiliation

Zhang S; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Tischer T; Max Planck Institute for Biophysical Chemistry, Göttingen, 37077, Germany.
Barford D; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Nat Commun ; 10(1): 3863, 2019 08 27.

Article in En | MEDLINE | ID: mdl-31455778

Subject(s)

Anaphase-Promoting Complex-Cyclosome/metabolism; Cyclin A2/metabolism; M Phase Cell Cycle Checkpoints/physiology; Ubiquitination/physiology; Amino Acid Motifs/physiology; Anaphase-Promoting Complex-Cyclosome/ultrastructure; CDC2-CDC28 Kinases/metabolism; CDC2-CDC28 Kinases/ultrastructure; Cdc20 Proteins/metabolism; Cdc20 Proteins/ultrastructure; Cell Cycle Proteins/metabolism; Cell Cycle Proteins/ultrastructure; Cryoelectron Microscopy; Cyclin A2/ultrastructure; HEK293 Cells; Humans; Intravital Microscopy; Models, Molecular; Protein Binding/physiology; Proteolysis; Spindle Apparatus/metabolism; Substrate Specificity/physiology

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Full text: 1 Database: MEDLINE Main subject: Ubiquitination / Cyclin A2 / M Phase Cell Cycle Checkpoints / Anaphase-Promoting Complex-Cyclosome Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Type: Article Affiliation country: United kingdom

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