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Design, synthesis, and biological evaluation of novel androst-17ß-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists.
Lao, Kejing; Xun, Guoliang; Gou, Xingchun; Xiang, Hua.
Affiliation
  • Lao K; Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University , Xi'an , PR China.
  • Xun G; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University , Nanjing , PR China.
  • Gou X; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing , PR China.
  • Xiang H; Abbisko Therapeutics Co Ltd , Shanghai , PR China.
J Enzyme Inhib Med Chem ; 34(1): 1597-1606, 2019 Dec.
Article in En | MEDLINE | ID: mdl-31469015
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Full text: 1 Database: MEDLINE Main subject: Drug Design / Receptors, Androgen / Cholestenone 5 alpha-Reductase / Androgen Receptor Antagonists / 5-alpha Reductase Inhibitors / Androstanes / Androstenes Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Drug Design / Receptors, Androgen / Cholestenone 5 alpha-Reductase / Androgen Receptor Antagonists / 5-alpha Reductase Inhibitors / Androstanes / Androstenes Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article