Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.

Schiroli, Davide; Gómara, María J; Maurizi, Eleonora; Atkinson, Sarah D; Mairs, Laura; Christie, Kathleen A; Cobice, Diego F; McCrudden, Cian M; Nesbit, M Andrew; Haro, Isabel; Moore, Tara

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.

Schiroli, Davide; Gómara, María J; Maurizi, Eleonora; Atkinson, Sarah D; Mairs, Laura; Christie, Kathleen A; Cobice, Diego F; McCrudden, Cian M; Nesbit, M Andrew; Haro, Isabel; Moore, Tara.

Affiliation

Schiroli D; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Gómara MJ; Unit of Synthesis and Biomedical Applications of Peptides, Department of Biomedical Chemistry, Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Barcelona, Spain.
Maurizi E; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Atkinson SD; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland; Northern Ireland Centre for Stratified Medicine, University of Ulster, Londonderry BT47 6SB, UK.
Mairs L; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Christie KA; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Cobice DF; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
McCrudden CM; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.
Nesbit MA; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland.
Haro I; Unit of Synthesis and Biomedical Applications of Peptides, Department of Biomedical Chemistry, Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Barcelona, Spain.
Moore T; Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, Northern Ireland. Electronic address: tara.moore@ulster.ac.uk.