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CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.
Wang, Cun; Wang, Hui; Lieftink, Cor; du Chatinier, Aimee; Gao, Dongmei; Jin, Guangzhi; Jin, Haojie; Beijersbergen, Roderick L; Qin, Wenxin; Bernards, René.
Affiliation
  • Wang C; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Wang H; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lieftink C; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • du Chatinier A; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Gao D; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Jin G; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China.
  • Jin H; Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
  • Beijersbergen RL; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Qin W; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Bernards R; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Gut ; 69(4): 727-736, 2020 04.
Article in En | MEDLINE | ID: mdl-31519701
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Carcinoma, Hepatocellular / Cyclin-Dependent Kinases / Sorafenib / Anilides / Liver Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Gut Year: 2020 Type: Article Affiliation country: Netherlands
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Carcinoma, Hepatocellular / Cyclin-Dependent Kinases / Sorafenib / Anilides / Liver Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Gut Year: 2020 Type: Article Affiliation country: Netherlands