Oral dosing for antenatal corticosteroids in the Rhesus macaque.

Schmidt, Augusto F; Kemp, Matthew W; Milad, Mark; Miller, Lisa A; Bridges, James P; Clarke, Michael W; Kannan, Paranthaman S; Jobe, Alan H

Schmidt, Augusto F; Kemp, Matthew W; Milad, Mark; Miller, Lisa A; Bridges, James P; Clarke, Michael W; Kannan, Paranthaman S; Jobe, Alan H.

Affiliation

Schmidt AF; Department of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America.
Kemp MW; University of Western Australia, Perth, Australia.
Milad M; Milad Pharmaceutical consulting LLC, Plymouth, Michigan, United States of America.
Miller LA; California National Primate Research Center, University of California, Davis, Davis, California, United States of America.
Bridges JP; Department of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America.
Clarke MW; Metabolomics Australia, Centre for Microscopy, Characterization and Analysis, The University of Western Australia, Perth, WA, Australia.
Kannan PS; Department of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America.
Jobe AH; Department of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America.

PLoS One ; 14(9): e0222817, 2019.

Article in En | MEDLINE | ID: mdl-31536601

Subject(s)

Adrenal Cortex Hormones/administration & dosage; Betamethasone/analogs & derivatives; Dexamethasone/analogs & derivatives; Models, Animal; Prenatal Care/methods; Administration, Oral; Adrenal Cortex Hormones/blood; Adrenal Cortex Hormones/pharmacokinetics; Animals; Betamethasone/administration & dosage; Betamethasone/blood; Betamethasone/pharmacokinetics; Dexamethasone/administration & dosage; Dexamethasone/blood; Dexamethasone/pharmacokinetics; Female; Fetal Organ Maturity/drug effects; Fetal Organ Maturity/genetics; Gene Expression Profiling/methods; Gene Expression Regulation, Developmental/drug effects; Hippocampus/drug effects; Hippocampus/embryology; Humans; Injections, Intramuscular; Liver/drug effects; Liver/embryology; Liver/metabolism; Lung/drug effects; Lung/embryology; Lung/metabolism; Macaca mulatta; Pregnancy; Premature Birth/genetics; Premature Birth/metabolism

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Full text: 1 Database: MEDLINE Main subject: Prenatal Care / Betamethasone / Dexamethasone / Adrenal Cortex Hormones / Models, Animal Type of study: Guideline / Prognostic_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2019 Type: Article Affiliation country: United States

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