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A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors.
Dasovich, Morgan; Leung, Anthony K L.
Affiliation
  • Dasovich M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: anthony.leung@jhu.edu.
Mol Cell ; 75(6): 1089-1091, 2019 09 19.
Article in En | MEDLINE | ID: mdl-31539506
ABSTRACT
In this issue of Molecular Cell, Kim et al. (2019) identify small nucleolar RNAs (snoRNAs) as activators of poly(ADP-ribose) (PAR) synthesis, demonstrating that this snoRNA-PAR partnership promotes cancer cell growth independent of DNA repair pathways.
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Full text: 1 Database: MEDLINE Main subject: RNA, Small Nucleolar / Poly(ADP-ribose) Polymerase Inhibitors Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: RNA, Small Nucleolar / Poly(ADP-ribose) Polymerase Inhibitors Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: United States