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Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia.
Vyas-Read, Shilpa; Wymore, Erica M; Zaniletti, Isabella; Murthy, Karna; Padula, Michael A; Truog, William E; Engle, William A; Savani, Rashmin C; Yallapragada, Sushmita; Logan, J Wells; Zhang, Huayan; Hysinger, Erik B; Grover, Theresa R; Natarajan, Girija; Nelin, Leif D; Porta, Nicolas F M; Potoka, Karin P; DiGeronimo, Robert; Lagatta, Joanne M.
Affiliation
  • Vyas-Read S; Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA. svyasre@emory.edu.
  • Wymore EM; Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
  • Zaniletti I; Children's Hospital Association, Lenexa, KS, USA.
  • Murthy K; Ann and Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Padula MA; Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Truog WE; Children's Mercy Hospital, University of Missouri, Kansas City, MO, USA.
  • Engle WA; Riley Hospital for Children, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Savani RC; University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Yallapragada S; University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Logan JW; Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
  • Zhang H; Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Hysinger EB; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Cincinnati, OH, USA.
  • Grover TR; Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
  • Natarajan G; Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.
  • Nelin LD; Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
  • Porta NFM; Ann and Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Potoka KP; Department of Pediatrics, Division of Newborn Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
  • DiGeronimo R; Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
  • Lagatta JM; Children's Hospital of Wisconsin, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
J Perinatol ; 40(1): 149-156, 2020 01.
Article in En | MEDLINE | ID: mdl-31570799
OBJECTIVE: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). STUDY DESIGN: Infants with sBPD in the Children's Hospitals Neonatal Database who had echocardiograms 34-44 weeks' postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. RESULTS: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2-3.0; RVSP OR 2.2, 95% CI 1.1-4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. CONCLUSIONS: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.
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Full text: 1 Database: MEDLINE Main subject: Blood Pressure / Bronchopulmonary Dysplasia / Infant, Premature / Echocardiography / Hospital Mortality / Ventricular Septum Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Newborn Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Blood Pressure / Bronchopulmonary Dysplasia / Infant, Premature / Echocardiography / Hospital Mortality / Ventricular Septum Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Newborn Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2020 Type: Article Affiliation country: United States