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Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.
Robichaux, Jacqulyne P; Elamin, Yasir Y; Vijayan, R S K; Nilsson, Monique B; Hu, Lemei; He, Junqin; Zhang, Fahao; Pisegna, Marlese; Poteete, Alissa; Sun, Huiying; Li, Shuai; Chen, Ting; Han, Han; Negrao, Marcelo Vailati; Ahnert, Jordi Rodon; Diao, Lixia; Wang, Jing; Le, Xiuning; Meric-Bernstam, Funda; Routbort, Mark; Roeck, Brent; Yang, Zane; Raymond, Victoria M; Lanman, Richard B; Frampton, Garrett M; Miller, Vincent A; Schrock, Alexa B; Albacker, Lee A; Wong, Kwok-Kin; Cross, Jason B; Heymach, John V.
Affiliation
  • Robichaux JP; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Elamin YY; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Vijayan RSK; Institute for Applied Cancer Science, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Nilsson MB; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Hu L; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • He J; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Zhang F; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Pisegna M; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Poteete A; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Sun H; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Li S; Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
  • Chen T; Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
  • Han H; Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
  • Negrao MV; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Ahnert JR; Investigative Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Diao L; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Wang J; Department of Hematopathology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Le X; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Meric-Bernstam F; Investigative Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Routbort M; Department of Hematopathology, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Roeck B; Spectrum Pharmaceuticals, Irvine, CA 92618, USA.
  • Yang Z; Spectrum Pharmaceuticals, Irvine, CA 92618, USA.
  • Raymond VM; Guardant Health, Inc., Redwood City, CA 94063, USA.
  • Lanman RB; Guardant Health, Inc., Redwood City, CA 94063, USA.
  • Frampton GM; Foundation Medicine, Cambridge, MA 02141, USA.
  • Miller VA; Foundation Medicine, Cambridge, MA 02141, USA.
  • Schrock AB; Foundation Medicine, Cambridge, MA 02141, USA.
  • Albacker LA; Foundation Medicine, Cambridge, MA 02141, USA.
  • Wong KK; Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
  • Cross JB; Institute for Applied Cancer Science, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jheymach@mdanderson.org.
Cancer Cell ; 36(4): 444-457.e7, 2019 10 14.
Article in En | MEDLINE | ID: mdl-31588020
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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Antineoplastic Combined Chemotherapy Protocols / Receptor, ErbB-2 / Ado-Trastuzumab Emtansine / Neoplasms Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Antineoplastic Combined Chemotherapy Protocols / Receptor, ErbB-2 / Ado-Trastuzumab Emtansine / Neoplasms Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2019 Type: Article Affiliation country: United States