Hypoxia Induced Heparan Sulfate Primes the Extracellular Matrix for Endothelial Cell Recruitment by Facilitating VEGF-Fibronectin Interactions.

Buczek-Thomas, Jo Ann; Rich, Celeste B; Nugent, Matthew A

Buczek-Thomas, Jo Ann; Rich, Celeste B; Nugent, Matthew A.

Affiliation

Buczek-Thomas JA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. jbuczek@bu.edu.
Rich CB; Department of Biochemistry, Boston University School of Medicine, Boston, MA 02215, USA. cbrich@bu.edu.
Nugent MA; Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA. matthew_nugent@uml.edu.

Int J Mol Sci ; 20(20)2019 Oct 12.

Article in En | MEDLINE | ID: mdl-31614727

Subject(s)

Endothelium, Vascular/metabolism; Extracellular Matrix/metabolism; Fibronectins/metabolism; Heparitin Sulfate/metabolism; Retinal Pigment Epithelium/metabolism; Vascular Endothelial Growth Factor A/metabolism; Animals; Cell Adhesion; Cell Hypoxia; Cell Line; Cells, Cultured; Endothelial Cells/metabolism; Endothelium, Vascular/cytology; Humans; Oxygen/metabolism; Rats; Retinal Pigment Epithelium/cytology

Key words

age-related macular degeneration; angiogenesis; endothelial cell; fibronectin; hypoxia; retina; vascular endothelial growth factor

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Full text: 1 Database: MEDLINE Main subject: Endothelium, Vascular / Fibronectins / Vascular Endothelial Growth Factor A / Extracellular Matrix / Retinal Pigment Epithelium / Heparitin Sulfate Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2019 Type: Article Affiliation country: United States

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