Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling.

Laval, Kathlyn; Van Cleemput, Jolien; Vernejoul, Jonah B; Enquist, Lynn W

Laval, Kathlyn; Van Cleemput, Jolien; Vernejoul, Jonah B; Enquist, Lynn W.

Affiliation

Laval K; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Van Cleemput J; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Vernejoul JB; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Enquist LW; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.

PLoS Pathog ; 15(11): e1008087, 2019 11.

Article in En | MEDLINE | ID: mdl-31675371

Subject(s)

Alphaherpesvirinae/immunology; Herpesviridae Infections/immunology; Inflammation/immunology; Interferon Type I/pharmacology; Neurons/immunology; Peripheral Nervous System/immunology; Toll-Like Receptor 2/metabolism; Alphaherpesvirinae/drug effects; Animals; Antiviral Agents/pharmacology; Herpesviridae Infections/drug therapy; Herpesviridae Infections/virology; Inflammation/drug therapy; Inflammation/virology; Male; Mice; Mice, Inbred C57BL; Neurons/drug effects; Neurons/virology; Peripheral Nervous System/drug effects; Peripheral Nervous System/virology; Toll-Like Receptor 2/genetics; Virus Replication

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Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Peripheral Nervous System / Alphaherpesvirinae / Herpesviridae Infections / Toll-Like Receptor 2 / Inflammation / Neurons Limits: Animals Language: En Journal: PLoS Pathog Year: 2019 Type: Article Affiliation country: United States

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