Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis.

Park, Christa; Cheung, Kitty P; Limon, Natalie; Costanzo, Anne; Barba, Cindy; Miranda, Nadia; Gargas, Shannon; Johnson, Andrew M F; Olefsky, Jerrold M; Jameson, Julie M

Park, Christa; Cheung, Kitty P; Limon, Natalie; Costanzo, Anne; Barba, Cindy; Miranda, Nadia; Gargas, Shannon; Johnson, Andrew M F; Olefsky, Jerrold M; Jameson, Julie M.

Affiliation

Park C; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Cheung KP; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Limon N; Department of Biology, Division of Molecular Biology, University of California San Diego, San Diego, CA 92093; and.
Costanzo A; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Barba C; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Miranda N; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Gargas S; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Johnson AMF; Department of Biology, California State University San Marcos, San Marcos, CA 92069.
Olefsky JM; Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093.
Jameson JM; Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093.

J Immunol ; 203(12): 3427-3435, 2019 12 15.

Article in En | MEDLINE | ID: mdl-31712385

Subject(s)

Colitis/etiology; Colitis/metabolism; Immunomodulation; Intraepithelial Lymphocytes/immunology; Intraepithelial Lymphocytes/metabolism; Obesity/immunology; Obesity/metabolism; Age Factors; Animals; Antigens, CD/genetics; Antigens, CD/metabolism; Biomarkers; Colitis/pathology; Dextran Sulfate/adverse effects; Diet, High-Fat; Disease Models, Animal; Fluorescent Antibody Technique; Gene Expression Regulation; Immunohistochemistry; Integrin alpha Chains/genetics; Integrin alpha Chains/metabolism; Male; Mice; Obesity/complications; Receptors, CCR/genetics; Receptors, CCR/metabolism; Receptors, Tumor Necrosis Factor/metabolism; Severity of Illness Index; Signal Transduction; Spleen/immunology; Spleen/metabolism; Thymus Gland/immunology; Thymus Gland/metabolism

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Full text: 1 Database: MEDLINE Main subject: Colitis / Immunomodulation / Intraepithelial Lymphocytes / Obesity Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2019 Type: Article

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