Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221.

Salama, Rania M; Abdel-Latif, Ghada A; Abbas, Samah S; El Magdoub, Hekmat M; Schaalan, Mona F

Salama, Rania M; Abdel-Latif, Ghada A; Abbas, Samah S; El Magdoub, Hekmat M; Schaalan, Mona F.

Affiliation

Salama RM; Pharmacology & Toxicology Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt; Translational and Clinical Research Unit, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: rania.salama@miuegypt.edu.eg.
Abdel-Latif GA; Pharmacology & Toxicology Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt; Translational and Clinical Research Unit, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: ghada.esmael@miuegypt.edu.eg.
Abbas SS; Pharmacology & Toxicology Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt; Translational and Clinical Research Unit, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: samah.saeed@miuegypt.edu.eg.
El Magdoub HM; Biochemistry Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt; Translational and Clinical Research Unit, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: hekmat.magdoub@miuegypt.edu.eg.
Schaalan MF; Pharmacy Practice & Clinical Pharmacy Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt; Translational and Clinical Research Unit, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt. Electronic address: mona.schaalan@miuegypt.edu.eg.

Neuropharmacology ; 164: 107900, 2020 03 01.

Article in En | MEDLINE | ID: mdl-31811872

Subject(s)

Carotenoids/pharmacology; MicroRNAs/biosynthesis; Neuroprotective Agents/pharmacology; Parkinson Disease, Secondary/chemically induced; Parkinson Disease, Secondary/drug therapy; Rotenone; Signal Transduction/drug effects; Uncoupling Agents; Animals; Behavior, Animal/drug effects; Male; MicroRNAs/drug effects; MicroRNAs/genetics; Oncogene Protein v-akt/drug effects; Parkinson Disease, Secondary/psychology; Phosphatidylinositol 3-Kinases/drug effects; Rats; Rats, Wistar; TOR Serine-Threonine Kinases/drug effects; Weight Loss/drug effects

Key words

Crocin; PI3K/Akt; Parkinson's disease; mTOR; miRNA-221; miRNA-7

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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease, Secondary / Rotenone / Uncoupling Agents / Carotenoids / Signal Transduction / Neuroprotective Agents / MicroRNAs Limits: Animals Language: En Journal: Neuropharmacology Year: 2020 Type: Article

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