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KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells.
Cordover, Emma; Wei, Janet; Patel, Chadni; Shan, Naing Lin; Gionco, John; Sargsyan, Davit; Wu, Renyi; Cai, Li; Kong, Ah-Ng; Jacinto, Estela; Minden, Audrey.
Affiliation
  • Cordover E; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Wei J; Department of Biochemistry and Molecular Biology , Rutgers-Robert Wood Johnson Medical School , 683 Hoes Lane , Piscataway , New Jersey 08854 , United States.
  • Patel C; Department of Biochemistry and Molecular Biology , Rutgers-Robert Wood Johnson Medical School , 683 Hoes Lane , Piscataway , New Jersey 08854 , United States.
  • Shan NL; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Gionco J; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Sargsyan D; Department of Pharmaceutics, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Wu R; Department of Pharmaceutics, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Cai L; Department of Biomedical Engineering , Rutgers, The State University of New Jersey , 599 Taylor Road , Piscataway , New Jersey 08854 , United States.
  • Kong AN; Department of Pharmaceutics, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
  • Jacinto E; Department of Biochemistry and Molecular Biology , Rutgers-Robert Wood Johnson Medical School , 683 Hoes Lane , Piscataway , New Jersey 08854 , United States.
  • Minden A; Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , 164 Frelinghuysen Road , Piscataway , New Jersey 08854 , United States.
Chem Res Toxicol ; 33(2): 482-491, 2020 02 17.
Article in En | MEDLINE | ID: mdl-31876149
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Full text: 1 Database: MEDLINE Main subject: Acrylamides / Down-Regulation / Cytokines / Nicotinamide Phosphoribosyltransferase / P21-Activated Kinases / Triple Negative Breast Neoplasms / Mechanistic Target of Rapamycin Complex 2 / Aminopyridines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Acrylamides / Down-Regulation / Cytokines / Nicotinamide Phosphoribosyltransferase / P21-Activated Kinases / Triple Negative Breast Neoplasms / Mechanistic Target of Rapamycin Complex 2 / Aminopyridines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: United States