Therapeutic Targeting of Vasculature in the Premetastatic and Metastatic Niches Reduces Lung Metastasis.

Ghouse, Shanawaz M; Vadrevu, Surya K; Manne, Sasikanth; Reese, Britney; Patel, Jalpa; Patel, Bhaumik; Silwal, Ashok; Lodhi, Niraj; Paterson, Yvonne; Srivastava, Sanjay K; Karbowniczek, Magdalena; Markiewski, Maciej M

Ghouse, Shanawaz M; Vadrevu, Surya K; Manne, Sasikanth; Reese, Britney; Patel, Jalpa; Patel, Bhaumik; Silwal, Ashok; Lodhi, Niraj; Paterson, Yvonne; Srivastava, Sanjay K; Karbowniczek, Magdalena; Markiewski, Maciej M.

Affiliation

Ghouse SM; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Vadrevu SK; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Manne S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and.
Reese B; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Patel J; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Patel B; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Silwal A; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Lodhi N; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Paterson Y; Department of Microbiology, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Srivastava SK; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Karbowniczek M; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601.
Markiewski MM; Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX 79601; maciej.markiewski@ttuhsc.edu.

J Immunol ; 204(4): 990-1000, 2020 02 15.

Article in En | MEDLINE | ID: mdl-31900334

Subject(s)

Cancer Vaccines/administration & dosage; Lung Neoplasms/therapy; Mammary Neoplasms, Experimental/therapy; Myeloid-Derived Suppressor Cells/immunology; Neovascularization, Pathologic/therapy; Angiogenesis Inhibitors/pharmacology; Angiogenesis Inhibitors/therapeutic use; Animals; Antineoplastic Agents, Immunological/pharmacology; Antineoplastic Agents, Immunological/therapeutic use; Cell Line, Tumor; Combined Modality Therapy/methods; Complement C5a/immunology; Complement C5a/metabolism; Female; Humans; Immunotherapy/methods; Listeria monocytogenes/immunology; Lung/blood supply; Lung/immunology; Lung/pathology; Lung Neoplasms/blood supply; Lung Neoplasms/immunology; Lung Neoplasms/secondary; Mammary Neoplasms, Experimental/immunology; Mammary Neoplasms, Experimental/pathology; Matrix Metalloproteinase 9/metabolism; Mice; Mice, Knockout; Myeloid-Derived Suppressor Cells/metabolism; Neoplasm Metastasis/immunology; Neoplasm Metastasis/therapy; Neovascularization, Pathologic/immunology; Receptor, Anaphylatoxin C5a/antagonists & inhibitors; Receptor, Anaphylatoxin C5a/genetics; Receptor, Anaphylatoxin C5a/metabolism; Tumor Microenvironment/immunology

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Full text: 1 Database: MEDLINE Main subject: Cancer Vaccines / Myeloid-Derived Suppressor Cells / Lung Neoplasms / Mammary Neoplasms, Experimental / Neovascularization, Pathologic Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2020 Type: Article

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