A pilot study to establish human T-cell leukemia virus type 1 (HTLV-1) carrier model using common marmoset (Callithrix jacchus).
J Med Primatol
; 49(2): 86-94, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-31930552
ABSTRACT
BACKGROUND:
For the diagnosis and treatment of adult T-cell leukemia/lymphoma (ATLL) caused by human T-lymphotropic virus type 1 (HTLV-1) are required therapeutic modalities urgently. Non-human primate models for ATLL would provide a valuable information for clinical studies. We did a pilot study to establish an ATLL non-human primate model using common marmosets (Callithrix jacchus).METHODS:
We inoculated HTLV-1-producing MT-2 cells into 9-month-old marmosets, either intraperitoneally or intravenously. We next administrated MT-2 cells into 13-month-old marmosets under cyclosporine A (CsA) treatment to promote infection. HTLV-1 infection was determined by measuring HTLV-1 antibody titer in the common marmosets.RESULTS:
The HTLV-1 antibody titer increased in the intraperitoneally inoculated marmoset with or without CsA treatment, and it kept over five 5 years though proviral copy number (proviral load, PVL) remained low throughout the study.CONCLUSION:
We obtained HTLV-1 asymptomatic carriers of common marmosets by inoculating MT-2 cells.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Callithrix
/
Human T-lymphotropic virus 1
/
Leukemia-Lymphoma, Adult T-Cell
/
Disease Models, Animal
Limits:
Animals
Language:
En
Journal:
J Med Primatol
Year:
2020
Type:
Article
Affiliation country:
Japan