The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation.
Acta Pharmacol Sin
; 41(5): 686-697, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-31932645
Full text:
1
Database:
MEDLINE
Main subject:
Apoptosis
/
Tumor Suppressor Proteins
/
STAT5 Transcription Factor
/
Quinolizidines
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Acta Pharmacol Sin
Journal subject:
FARMACOLOGIA
Year:
2020
Type:
Article
Affiliation country:
China