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The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation.
Zhao, Wu-Li; Xing, Yan; Ye, Cheng; Qiu, Yu-Han; Li, Yi; Liu, Xiu-Jun; Wang, Meng-Yan; Bi, Chong-Wen; Song, Dan-Qing; Shao, Rong-Guang.
Affiliation
  • Zhao WL; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Xing Y; Department of Pediatrics, Peking University Third Hospital, Beijing, 100083, China.
  • Ye C; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Qiu YH; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Li Y; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Liu XJ; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Wang MY; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Bi CW; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Song DQ; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. songdanqing@imb.pumc.edu.cn.
  • Shao RG; Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. rgshao@163.com.
Acta Pharmacol Sin ; 41(5): 686-697, 2020 May.
Article in En | MEDLINE | ID: mdl-31932645
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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Tumor Suppressor Proteins / STAT5 Transcription Factor / Quinolizidines / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Tumor Suppressor Proteins / STAT5 Transcription Factor / Quinolizidines / Antineoplastic Agents Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Type: Article Affiliation country: China