An example of how to establish the thermodynamic stability relationship between two polymorphs of a compound highly prone to solvate formation.

Nagel, Norbert; Baumgartner, Bruno; Berchtold, Harald

Nagel, Norbert; Baumgartner, Bruno; Berchtold, Harald.

Affiliation

Nagel N; Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, 65926 Frankfurt, Germany. Electronic address: norbert.nagel@abbvie.com.
Baumgartner B; Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, 65926 Frankfurt, Germany.
Berchtold H; Sanofi-Aventis Deutschland GmbH, R&D, Industriepark Höchst, 65926 Frankfurt, Germany.

Eur J Pharm Sci ; 145: 105215, 2020 Mar 30.

Article in En | MEDLINE | ID: mdl-31954182

Subject(s)

Anilides/chemical synthesis; Crystallization/methods; Solvents/chemical synthesis; Thermodynamics; Calorimetry, Differential Scanning/methods; Powder Diffraction/methods; X-Ray Diffraction/methods

Key words

Crystallization behavior; Differential scanning calorimetry; Polymorphism; Solution calorimetry; Thermodynamic stability relationship; X-ray powder diffraction; eutectic melting

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Full text: 1 Database: MEDLINE Main subject: Solvents / Thermodynamics / Crystallization / Anilides Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2020 Type: Article

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