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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Engelberts, Patrick J; Hiemstra, Ida H; de Jong, Bart; Schuurhuis, Danita H; Meesters, Joyce; Beltran Hernandez, Irati; Oostindie, Simone C; Neijssen, Joost; van den Brink, Edward N; Horbach, G Jean; Verploegen, Sandra; Labrijn, Aran F; Salcedo, Theodora; Schuurman, Janine; Parren, Paul W H I; Breij, Esther C W.
Affiliation
  • Engelberts PJ; Genmab, Utrecht, The Netherlands.
  • Hiemstra IH; Genmab, Utrecht, The Netherlands.
  • de Jong B; Genmab, Utrecht, The Netherlands.
  • Schuurhuis DH; Genmab, Utrecht, The Netherlands.
  • Meesters J; Genmab, Utrecht, The Netherlands.
  • Beltran Hernandez I; Genmab, Utrecht, The Netherlands.
  • Oostindie SC; Genmab, Utrecht, The Netherlands; Dept of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
  • Neijssen J; Genmab, Utrecht, The Netherlands.
  • van den Brink EN; Genmab, Utrecht, The Netherlands.
  • Horbach GJ; Genmab, Utrecht, The Netherlands.
  • Verploegen S; Genmab, Utrecht, The Netherlands.
  • Labrijn AF; Genmab, Utrecht, The Netherlands.
  • Salcedo T; Genmab, Utrecht, The Netherlands.
  • Schuurman J; Genmab, Utrecht, The Netherlands.
  • Parren PWHI; Genmab, Utrecht, The Netherlands; Dept of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
  • Breij ECW; Genmab, Utrecht, The Netherlands. Electronic address: EBJ@genmab.com.
EBioMedicine ; 52: 102625, 2020 Feb.
Article in En | MEDLINE | ID: mdl-31981978
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Full text: 1 Database: MEDLINE Main subject: Lymphocyte Activation / T-Lymphocytes / CD3 Complex / Antibodies, Bispecific / Antigens, CD20 / Cytotoxicity, Immunologic Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: EBioMedicine Year: 2020 Type: Article Affiliation country: Netherlands
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Lymphocyte Activation / T-Lymphocytes / CD3 Complex / Antibodies, Bispecific / Antigens, CD20 / Cytotoxicity, Immunologic Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: EBioMedicine Year: 2020 Type: Article Affiliation country: Netherlands