Intrapleural alteplase therapy: what are the knowns and unknowns?
Cas Lek Cesk
; 158(7-8): 295-299, 2019.
Article
in En
| MEDLINE
| ID: mdl-31995996
ABSTRACT
In pneumology, enzymatic properties of plasmin are used to disrupt fibrin adhesions and septations formed during pathological conditions of the pleural cavity. In that case, fibrinolytics are administrated locally via a chest tube in the pleural cavity to evacuate pathological effusion. Although the first intrapleural administration of fibrinolytic occurred seventy years ago, there has been no consensus on dosing or a uniform procedure of their application. The aim of the article is to summarize current knowledge of alteplase usage in pneumology and discuss practical aspects of its intrapleural application regarding specific possibilities in the Czech Republic.
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Database:
MEDLINE
Main subject:
Pleural Effusion
/
Empyema, Pleural
/
Tissue Plasminogen Activator
/
Fibrinolytic Agents
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Cas Lek Cesk
Year:
2019
Type:
Article