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Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study.
Geritz, Johanna; Maetzold, Sara; Steffen, Maren; Pilotto, Andrea; Corrà, Marta F; Moscovich, Mariana; Rizzetti, Maria C; Borroni, Barbara; Padovani, Alessandro; Alpes, Annekathrin; Bang, Corinna; Barcellos, Igor; Baron, Ralf; Bartsch, Thorsten; Becktepe, Jos S; Berg, Daniela; Bergeest, Lu M; Bergmann, Philipp; Bouça-Machado, Raquel; Drey, Michael; Elshehabi, Morad; Farahmandi, Susan; Ferreira, Joaquim J; Franke, Andre; Friederich, Anja; Geisler, Corinna; Hüllemann, Philipp; Gierthmühlen, Janne; Granert, Oliver; Heinzel, Sebastian; Heller, Maren K; Hobert, Markus A; Hofmann, Marc; Jemlich, Björn; Kerkmann, Laura; Knüpfer, Stephanie; Krause, Katharina; Kress, Maximilian; Krupp, Sonja; Kudelka, Jennifer; Kuhlenbäumer, Gregor; Kurth, Roland; Leypoldt, Frank; Maetzler, Corina; Maia, Luis F; Moewius, Andreas; Neumann, Patricia; Niemann, Katharina; Ortlieb, Christian T; Paschen, Steffen.
Affiliation
  • Geritz J; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany. j.geritz@neurologie.uni-kiel.de.
  • Maetzold S; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Steffen M; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Pilotto A; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
  • Corrà MF; Neurology Department, Centro Hospitalar do Porto, Porto, Portugal.
  • Moscovich M; Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.
  • Rizzetti MC; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
  • Borroni B; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
  • Padovani A; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
  • Alpes A; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Bang C; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Barcellos I; Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.
  • Baron R; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Bartsch T; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Becktepe JS; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Berg D; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Bergeest LM; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Bergmann P; Department of Internal Medicine I, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Bouça-Machado R; Instituto de Medicina Molecular, Lisbon, Portugal. CNS-Campus Neurológico Sénior, Torres Vedras, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
  • Drey M; Medical Clinic and Policlinic IV, Ludwig-Maximilians-University of Munich, Munich, Germany.
  • Elshehabi M; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Farahmandi S; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Ferreira JJ; Instituto de Medicina Molecular, Lisbon, Portugal. CNS-Campus Neurológico Sénior, Torres Vedras, Portugal. Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
  • Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Friederich A; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Geisler C; Institute of Human nutrition, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Hüllemann P; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Gierthmühlen J; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Granert O; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Heinzel S; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Heller MK; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Hobert MA; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Hofmann M; Hasomed GmbH, Magdeburg, Germany.
  • Jemlich B; Third Medical Clinic for Gastroenterology/Rheumatology, Städtisches Krankenhaus Kiel, Kiel, Germany.
  • Kerkmann L; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Knüpfer S; Department of Urology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Krause K; Department of Internal Medicine I, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Kress M; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Krupp S; Research Group Geriatrics Lübeck, Red Cross Hospital Geriatric Centre, Lübeck, Germany.
  • Kudelka J; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Kuhlenbäumer G; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Kurth R; Department of Psychiatry and Psychotherapy, ZIP, Centre for Integrative Psychiatry, Kiel, Germany.
  • Leypoldt F; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Maetzler C; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Maia LF; Neurology Department, Centro Hospitalar do Porto, Porto, Portugal.
  • Moewius A; Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Bochum, Germany.
  • Neumann P; Department of Neurology, Asklepios Klinik Barmbek, Hamburg, Germany.
  • Niemann K; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Ortlieb CT; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Paschen S; Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
BMC Geriatr ; 20(1): 45, 2020 02 06.
Article in En | MEDLINE | ID: mdl-32028945
BACKGROUND: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). METHODS: This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. DISCUSSION: This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.
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Full text: 1 Database: MEDLINE Main subject: Accidental Falls / Activities of Daily Living Type of study: Clinical_trials / Guideline / Observational_studies Limits: Aged / Humans Country/Region as subject: America do sul / Brasil / Europa Language: En Journal: BMC Geriatr Journal subject: GERIATRIA Year: 2020 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Accidental Falls / Activities of Daily Living Type of study: Clinical_trials / Guideline / Observational_studies Limits: Aged / Humans Country/Region as subject: America do sul / Brasil / Europa Language: En Journal: BMC Geriatr Journal subject: GERIATRIA Year: 2020 Type: Article Affiliation country: Germany