Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.

Li, Xue; Kong, Lingmei; Yang, Qihong; Duan, Aizhu; Ju, Xiaoman; Cai, Bicheng; Chen, Lin; An, Tao; Li, Yan

Li, Xue; Kong, Lingmei; Yang, Qihong; Duan, Aizhu; Ju, Xiaoman; Cai, Bicheng; Chen, Lin; An, Tao; Li, Yan.

Affiliation

Li X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Kong L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Yang Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Duan A; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Ju X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Cai B; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Chen L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
An T; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic
Li Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic

J Biol Chem ; 295(11): 3576-3589, 2020 03 13.

Article in En | MEDLINE | ID: mdl-32029476

Subject(s)

Colorectal Neoplasms/enzymology; Colorectal Neoplasms/pathology; Sesquiterpenes/pharmacology; Ubiquitin-Specific Peptidase 7/antagonists & inhibitors; Wnt Signaling Pathway/drug effects; 4-Butyrolactone/analogs & derivatives; 4-Butyrolactone/chemistry; 4-Butyrolactone/pharmacology; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Colorectal Neoplasms/genetics; Down-Regulation/drug effects; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; HEK293 Cells; Humans; Proteolysis/drug effects; Sesquiterpenes/chemistry; Ubiquitin-Specific Peptidase 7/metabolism; Ubiquitination/drug effects; beta Catenin/metabolism

Key words

USP7; Wnt signaling; colorectal cancer; deubiquitinating activity; deubiquitylation (deubiquitination); enzyme inhibitor; parthenolide; pharmacology; proteasome system; protein homeostasis; small molecule; ubiquitin-specific peptidase 7; ubiquitination; ß-catenin

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Full text: 1 Database: MEDLINE Main subject: Sesquiterpenes / Colorectal Neoplasms / Wnt Signaling Pathway / Ubiquitin-Specific Peptidase 7 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article Affiliation country: China

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