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Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.
Myers, Michael C; Bilder, Donna M; Cavallaro, Cullen L; Chao, Hannguang J; Su, Shun; Burford, Neil T; Nayeem, Akbar; Wang, Tao; Yan, Mujing; Langish, Robert A; Dabros, Marta; Li, Yi-Xin; Rose, Anne V; Behnia, Kamelia; Onorato, Joelle M; Gargalovic, Peter S; Wexler, Ruth R; Lawrence, R Michael.
Affiliation
  • Myers MC; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States. Electronic address: michael.myers@bms.com.
  • Bilder DM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Cavallaro CL; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Chao HJ; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Su S; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Burford NT; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Nayeem A; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Wang T; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Yan M; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Langish RA; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Dabros M; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Li YX; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Rose AV; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Behnia K; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Onorato JM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Gargalovic PS; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Wexler RR; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
  • Lawrence RM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.
Bioorg Med Chem Lett ; 30(7): 126955, 2020 04 01.
Article in En | MEDLINE | ID: mdl-32035698
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Full text: 1 Database: MEDLINE Main subject: Pyrimidinones / Apelin Receptors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrimidinones / Apelin Receptors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article