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Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.
Dargue, Rebecca; Zia, Rabiya; Lau, Chungho; Nicholls, Andrew W; Dare, Theo O; Lee, Karla; Jalan, Rajiv; Coen, Muireann; Wilson, Ian D.
Affiliation
  • Dargue R; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK.
  • Zia R; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK.
  • Lau C; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK.
  • Nicholls AW; GSK R&D, Ware, Hertfordshire SG12 0DP, UK.
  • Dare TO; GSK R&D, Ware, Hertfordshire SG12 0DP, UK.
  • Lee K; Department of Clinical Science and Services, Royal Veterinary College, University of London, Hertfordshire AL9 7TA, UK.
  • Jalan R; UCL Institute for Liver and Digestive Health, Royal Free Hospital, London NW3 2PF, UK.
  • Coen M; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, UK.
  • Wilson ID; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Toxicol Sci ; 175(1): 87-97, 2020 05 01.
Article in En | MEDLINE | ID: mdl-32061126
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Full text: 1 Database: MEDLINE Main subject: Mitochondria, Liver / Liver Failure / Chemical and Drug Induced Liver Injury / Liver / Acetaminophen Type of study: Etiology_studies Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Mitochondria, Liver / Liver Failure / Chemical and Drug Induced Liver Injury / Liver / Acetaminophen Type of study: Etiology_studies Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2020 Type: Article Affiliation country: United kingdom