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Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer.
Tsuchihashi, Yuki; Abe, Shinji; Miyamoto, Licht; Tsunematsu, Honoka; Izumi, Toshihiro; Hatano, Aya; Okuno, Hiroko; Yamane, Megumi; Yasuoka, Takashi; Ikeda, Yasumasa; Tsuchiya, Koichiro.
Affiliation
  • Tsuchihashi Y; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Abe S; Department of Clinical Pharmacy Practice Pedagogy, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Miyamoto L; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Tsunematsu H; Department of Bioorganic Synthetic Chemistry, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Izumi T; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Hatano A; Department of Clinical Pharmacy Practice Pedagogy, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Okuno H; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Yamane M; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Yasuoka T; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Ikeda Y; Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.
  • Tsuchiya K; Department of Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 770-8505, Japan.
Mol Pharm ; 17(4): 1049-1058, 2020 04 06.
Article in En | MEDLINE | ID: mdl-32068412

Full text: 1 Database: MEDLINE Main subject: Camptothecin / Diarrhea / Glycerol / Lung Neoplasms / Antineoplastic Agents, Phytogenic Limits: Animals / Humans / Male Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2020 Type: Article Affiliation country: Japan

Full text: 1 Database: MEDLINE Main subject: Camptothecin / Diarrhea / Glycerol / Lung Neoplasms / Antineoplastic Agents, Phytogenic Limits: Animals / Humans / Male Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2020 Type: Article Affiliation country: Japan