RNA-Seq Analysis of Genetic and Transcriptome Network Effects of Dual-Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models.

Kozell, Laura B; Lockwood, Denesa; Darakjian, Priscila; Edmunds, Stephanie; Shepherdson, Karen; Buck, Kari J; Hitzemann, Robert

Kozell, Laura B; Lockwood, Denesa; Darakjian, Priscila; Edmunds, Stephanie; Shepherdson, Karen; Buck, Kari J; Hitzemann, Robert.

Affiliation

Kozell LB; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Lockwood D; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Darakjian P; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Edmunds S; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Shepherdson K; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Buck KJ; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.
Hitzemann R; From the, Department of Behavioral Neuroscience, VA Portland Health Care System, Oregon Health & Science University, Portland, Oregon.

Alcohol Clin Exp Res ; 44(4): 820-830, 2020 04.

Article in En | MEDLINE | ID: mdl-32090358

Subject(s)

Alcohol Drinking/genetics; Behavior, Animal; Central Nervous System Depressants/administration & dosage; Ethanol/administration & dosage; Substance Withdrawal Syndrome/genetics; Animals; Central Nervous System Depressants/adverse effects; Ethanol/adverse effects; Gene Expression Profiling; Guanylate Kinases/genetics; Membrane Proteins/genetics; Mice; Models, Genetic; NADH Dehydrogenase/genetics; NEDD8 Protein/genetics; Protocadherins/genetics; RNA-Seq; Receptors, GABA-A/genetics; Receptors, Glutamate/genetics; Receptors, Metabotropic Glutamate/genetics; Receptors, N-Methyl-D-Aspartate/genetics; Substance Withdrawal Syndrome/etiology; Vacuolar Proton-Translocating ATPases/genetics

Key words

Alcohol; Dual-Trait Selective Breeding; Genetics; Mouse; RNA-Seq; Transcriptome Sequencing; Ventral Striatum; Weighted Gene Co-expression Network Analysis

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Full text: 1 Database: MEDLINE Main subject: Substance Withdrawal Syndrome / Behavior, Animal / Alcohol Drinking / Central Nervous System Depressants / Ethanol Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Alcohol Clin Exp Res Year: 2020 Type: Article

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