Alteration in the sensitivity to crizotinib by Na<sup>+</sup>/H<sup>+</sup> exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers.

Yang, Fenglian; Hu, Mu; Chang, Siyuan; Huang, Jing; Si, Yang; Wang, Jinghui; Cheng, Shan; Jiang, Wen G

Alteration in the sensitivity to crizotinib by Na⁺/H⁺ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers.

Yang, Fenglian; Hu, Mu; Chang, Siyuan; Huang, Jing; Si, Yang; Wang, Jinghui; Cheng, Shan; Jiang, Wen G.

Affiliation

Yang F; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Hu M; Beijing Key Laboratory of Cancer & Metastasis Research, Capital Medical University, Beijing, China.
Chang S; Beijing Key Laboratory of Cancer & Metastasis Research, Capital Medical University, Beijing, China.
Huang J; Department of Thoracic Surgery, Beijing Xuanwu Hospital, Beijing, 100053, P.R. China.
Si Y; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Wang J; Beijing Key Laboratory of Cancer & Metastasis Research, Capital Medical University, Beijing, China.
Cheng S; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People's Republic of China.
Jiang WG; Beijing Key Laboratory of Cancer & Metastasis Research, Capital Medical University, Beijing, China.

BMC Cancer ; 20(1): 202, 2020 Mar 12.

Article in En | MEDLINE | ID: mdl-32164629

Subject(s)

Anaplastic Lymphoma Kinase/metabolism; Carcinoma, Non-Small-Cell Lung/metabolism; Crizotinib/pharmacology; Lung Neoplasms/metabolism; Phosphoproteins/metabolism; Sodium-Hydrogen Exchangers/metabolism; Up-Regulation; Anaplastic Lymphoma Kinase/genetics; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; Cell Line, Tumor; Cell Nucleus/metabolism; Cell Proliferation/drug effects; Cell Survival/drug effects; Cytosol/metabolism; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic/drug effects; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Phosphoproteins/genetics; Sodium-Hydrogen Exchangers/genetics

Key words

ALK; Crizotinib; Lung cancer; NHERF1; PDZ protein

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Full text: 1 Database: MEDLINE Main subject: Phosphoproteins / Up-Regulation / Sodium-Hydrogen Exchangers / Carcinoma, Non-Small-Cell Lung / Crizotinib / Anaplastic Lymphoma Kinase / Lung Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2020 Type: Article

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