Two high-performance liquid chromatography-tandem mass spectrometry methods for determination of edaravone and taurine in human plasma: Application to drug-drug interaction and pharmacokinetic studies.

Li, Le; Zhao, Shunbo; Xu, Lingyan; Su, Yuwen; Ding, Li

Li, Le; Zhao, Shunbo; Xu, Lingyan; Su, Yuwen; Ding, Li.

Affiliation

Li L; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, P. R. China.
Zhao S; Nanjing Clinical Tech. Laboratories Inc., Nanjing, P. R. China.
Xu L; School of Pharmacy, Nanjing Medical University, Nanjing, P. R. China.
Su Y; School of Pharmacy, Nanjing Medical University, Nanjing, P. R. China.
Ding L; Department of Clinical Pharmacology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, P. R. China.

J Sep Sci ; 43(12): 2279-2289, 2020 Jun.

Article in En | MEDLINE | ID: mdl-32175680

Subject(s)

Edaravone/blood; Edaravone/pharmacokinetics; Taurine/blood; Taurine/pharmacology; Calibration; Chromatography, High Pressure Liquid; Drug Interactions; Edaravone/administration & dosage; Healthy Volunteers; Humans; Infusions, Intravenous; Quality Control; Tandem Mass Spectrometry; Taurine/administration & dosage; Tissue Distribution

Key words

drug interactions; edaravone; mass spectrometry; pharmacokinetics; taurine

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Full text: 1 Database: MEDLINE Main subject: Taurine / Edaravone Limits: Humans Language: En Journal: J Sep Sci Year: 2020 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Taurine / Edaravone Limits: Humans Language: En Journal: J Sep Sci Year: 2020 Type: Article