Burden of Adults Hospitalized With Group B Streptococcal Infection.
J Infect Dis
; 224(7): 1170-1178, 2021 10 13.
Article
in En
| MEDLINE
| ID: mdl-32188975
ABSTRACT
BACKGROUND:
The burden of noninvasive group B Streptococcus (GBS) infections in adults is unknown. We determined population-based rates of hospitalization where invasive or noninvasive GBS infections were identified among US adults in a defined catchment area.METHODS:
We identified adults with clinical and laboratory-confirmed evidence of GBS infection from January 2014 through December 2016 from 6 hospitals in Louisville, Kentucky. Invasive disease was defined as GBS isolated from a normally sterile site.RESULTS:
Among 1076 adults with GBS infection, the median age was 52 years, 51% were male, and 89% hadâ ≥1 chronic medical condition. The most prevalent infection sites were skin and soft tissue (39%), urinary tract (23%), bone and joint (16%), and bloodstream (11%). Forty percent of infections were polymicrobial. The annual incidence of GBS-associated hospitalization was 73 per 100 000 adults and 68 and 100 per 100 000 for patients aged 18-64 and ≥ 65 years, respectively. For every invasive GBS infection, 3.7 noninvasive infections occurred.CONCLUSIONS:
Our population-based study outlines the full burden of GBS-associated hospitalization in adults and found incidence rates comparable to those of pneumococcal disease, where vaccines are recommended. Noninvasive disease was 3-4 times more common than invasive disease, suggesting that the GBS burden among adults is considerably greater than previously recognized.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Streptococcal Infections
/
Streptococcus agalactiae
/
Hospitalization
Type of study:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
J Infect Dis
Year:
2021
Type:
Article
Affiliation country:
United States