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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
Mohamed, Eslam; Sierra, Rosa A; Trillo-Tinoco, Jimena; Cao, Yu; Innamarato, Patrick; Payne, Kyle K; de Mingo Pulido, Alvaro; Mandula, Jessica; Zhang, Shuzhong; Thevenot, Paul; Biswas, Subir; Abdalla, Sarah K; Costich, Tara Lee; Hänggi, Kay; Anadon, Carmen M; Flores, Elsa R; Haura, Eric B; Mehrotra, Shikhar; Pilon-Thomas, Shari; Ruffell, Brian; Munn, David H; Cubillos-Ruiz, Juan R; Conejo-Garcia, Jose R; Rodriguez, Paulo C.
Affiliation
  • Mohamed E; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Sierra RA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Trillo-Tinoco J; Bristol-Myers Squibb, Devens, MA 01434, USA.
  • Cao Y; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Innamarato P; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Payne KK; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • de Mingo Pulido A; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Mandula J; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Zhang S; Center for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Thevenot P; Institute of Translational Research, Ochsner Health System, New Orleans, LA 70121, USA.
  • Biswas S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Abdalla SK; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Costich TL; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Hänggi K; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Flores ER; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Haura EB; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Mehrotra S; Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Pilon-Thomas S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Ruffell B; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Munn DH; Department of Pediatrics, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
  • Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
  • Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: Paulo.Rodriguez@Moffitt.org.
Immunity ; 52(4): 668-682.e7, 2020 04 14.
Article in En | MEDLINE | ID: mdl-32294407
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Full text: 1 Database: MEDLINE Main subject: Skin Neoplasms / Melanoma, Experimental / Gene Expression Regulation, Neoplastic / Carcinoma, Lewis Lung / EIF-2 Kinase / Carcinoma, Ovarian Epithelial / Membrane Proteins Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Skin Neoplasms / Melanoma, Experimental / Gene Expression Regulation, Neoplastic / Carcinoma, Lewis Lung / EIF-2 Kinase / Carcinoma, Ovarian Epithelial / Membrane Proteins Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Type: Article Affiliation country: United States