PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.

Wang, Bo; Gan, Weidong; Han, Xiaodong; Li, Dongmei

Wang, Bo; Gan, Weidong; Han, Xiaodong; Li, Dongmei.

Affiliation

Wang B; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, China.
Gan W; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu, China.
Han X; Department of Urology, Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, Jiangsu, China.
Li D; Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, China.

Cell Biol Int ; 44(8): 1727-1733, 2020 Aug.

Article in En | MEDLINE | ID: mdl-32339358

Subject(s)

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics; Carcinoma, Renal Cell/metabolism; Dynamins/metabolism; Kidney Neoplasms/metabolism; Mitochondrial Dynamics; Mitochondrial Proteins/metabolism; Neoplasm Proteins/genetics; Oncogene Proteins, Fusion/genetics; Carcinoma, Renal Cell/genetics; Carcinoma, Renal Cell/pathology; Cell Line, Tumor; Cell Movement; Humans; Kidney Neoplasms/genetics; Kidney Neoplasms/pathology; Mitochondria/metabolism; Neoplasm Invasiveness; Translocation, Genetic

Key words

PRCC-TFE3; invasion; migration; mitochondrial fission; tRCC

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Renal Cell / Oncogene Proteins, Fusion / Mitochondrial Proteins / Dynamins / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Mitochondrial Dynamics / Kidney Neoplasms / Neoplasm Proteins Limits: Humans Language: En Journal: Cell Biol Int Year: 2020 Type: Article Affiliation country: China

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