Transforming growth factor ß (TGF-ß) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation.

Cattley, Richard T; Lee, Mijoon; Boggess, William C; Hawse, William F

Cattley, Richard T; Lee, Mijoon; Boggess, William C; Hawse, William F.

Affiliation

Cattley RT; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lee M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Boggess WC; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Hawse WF; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA whawse@pitt.edu.

J Biol Chem ; 295(24): 8236-8251, 2020 06 12.

Article in En | MEDLINE | ID: mdl-32358062

Subject(s)

Lymphocyte Activation/immunology; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism; Phosphatidylinositols/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Signal Transduction; T-Lymphocytes/immunology; Animals; CD4-Positive T-Lymphocytes/immunology; Enzyme Activation; Enzyme Stability; Mice, Inbred C57BL; PTEN Phosphohydrolase/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation; Phosphotyrosine/metabolism; Protein Binding; Protein Multimerization; Smad3 Protein/antagonists & inhibitors; Smad3 Protein/metabolism; Smad4 Protein/metabolism; ZAP-70 Protein-Tyrosine Kinase/metabolism

Key words

C-terminal Src kinase (CSK); T cell; T-cell biology; T-cell receptor (TCR); computer modeling; cytokine; immunity; phosphatase and tensin homolog (PTEN); phosphatidylinositide 3-kinase (PI 3-kinase); phosphatidylinositol; phosphatidylinositol kinase (PI kinase); phosphatidylinositol signaling; phosphoinositide 3-kinase (PI3K); phospholipid signaling; protein kinase A (PKA); transforming growth factor ß (TGF-ß)

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Full text: 1 Database: MEDLINE Main subject: Phosphatidylinositols / Lymphocyte Activation / T-Lymphocytes / Signal Transduction / Receptors, Transforming Growth Factor beta / Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2020 Type: Article Affiliation country: United States

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