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Development of CDK2 and CDK5 Dual Degrader TMX-2172.
Teng, Mingxing; Jiang, Jie; He, Zhixiang; Kwiatkowski, Nicholas P; Donovan, Katherine A; Mills, Caitlin E; Victor, Chiara; Hatcher, John M; Fischer, Eric S; Sorger, Peter K; Zhang, Tinghu; Gray, Nathanael S.
Affiliation
  • Teng M; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Jiang J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • He Z; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Kwiatkowski NP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Mills CE; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Victor C; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Hatcher JM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Sorger PK; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Zhang T; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Gray NS; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Angew Chem Int Ed Engl ; 59(33): 13865-13870, 2020 08 10.
Article in En | MEDLINE | ID: mdl-32415712
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / Cyclin-Dependent Kinase 5 / Cyclin-Dependent Kinase 2 Limits: Female / Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2020 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / Cyclin-Dependent Kinase 5 / Cyclin-Dependent Kinase 2 Limits: Female / Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2020 Type: Article Affiliation country: United States