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Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.
Yang, Huiming; Yang, Su; Jing, Liang; Huang, Luoxiu; Chen, Luxiao; Zhao, Xianxian; Yang, Weili; Pan, Yongcheng; Yin, Peng; Qin, Zhaohui S; Tang, Beisha; Li, Shihua; Li, Xiao-Jiang.
Affiliation
  • Yang H; Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China.
  • Yang S; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, 510632, Guangzhou, China.
  • Jing L; Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
  • Huang L; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Chen L; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, 510632, Guangzhou, China.
  • Zhao X; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Yang W; Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
  • Pan Y; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Yin P; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
  • Qin ZS; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, 510632, Guangzhou, China.
  • Tang B; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, 510632, Guangzhou, China.
  • Li S; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Li XJ; Department of Neurology & Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Hunan, China.
Nat Commun ; 11(1): 2582, 2020 05 22.
Article in En | MEDLINE | ID: mdl-32444599
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease / Huntingtin Protein Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease / Huntingtin Protein Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Type: Article Affiliation country: China