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Illuminating Genetic Mysteries of the Dead Sea Scrolls.
Anava, Sarit; Neuhof, Moran; Gingold, Hila; Sagy, Or; Munters, Arielle; Svensson, Emma M; Afshinnekoo, Ebrahim; Danko, David; Foox, Jonathan; Shor, Pnina; Riestra, Beatriz; Huchon, Dorothée; Mason, Christopher E; Mizrahi, Noam; Jakobsson, Mattias; Rechavi, Oded.
Affiliation
  • Anava S; Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
  • Neuhof M; Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
  • Gingold H; Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
  • Sagy O; Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
  • Munters A; Human Evolution, Department of Organismal Biology and SciLife Lab, Uppsala University, 751 05 Uppsala, Sweden.
  • Svensson EM; Human Evolution, Department of Organismal Biology and SciLife Lab, Uppsala University, 751 05 Uppsala, Sweden.
  • Afshinnekoo E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The WorldQuant Initiative for Quantitate Prediction, New York, NY
  • Danko D; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The WorldQuant Initiative for Quantitate Prediction, New York, NY
  • Foox J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The WorldQuant Initiative for Quantitate Prediction, New York, NY
  • Shor P; Dead Sea Scroll Projects, Israel Antiquities Authority, Jerusalem 91710, Israel.
  • Riestra B; Dead Sea Scroll Projects, Israel Antiquities Authority, Jerusalem 91710, Israel.
  • Huchon D; Steinhardt Museum of Natural History and Israel National Center for Biodiversity Studies, Tel-Aviv University, Tel-Aviv 6997801, Israel; Department of Zoology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.
  • Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; The WorldQuant Initiative for Quantitate Prediction, New York, NY
  • Mizrahi N; Department of Biblical Studies, The Lester and Sally Entin Faculty of Humanities, Tel Aviv University, Tel-Aviv 6997801, Israel. Electronic address: noam.m.mizrahi@gmail.com.
  • Jakobsson M; Human Evolution, Department of Organismal Biology and SciLife Lab, Uppsala University, 751 05 Uppsala, Sweden. Electronic address: mattias.jakobsson@ebc.uu.se.
  • Rechavi O; Department of Neurobiology, George Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel. Electronic address: odedrechavi@gmail.com.
Cell ; 181(6): 1218-1231.e27, 2020 06 11.
Article in En | MEDLINE | ID: mdl-32492404
The discovery of the 2,000-year-old Dead Sea Scrolls had an incomparable impact on the historical understanding of Judaism and Christianity. "Piecing together" scroll fragments is like solving jigsaw puzzles with an unknown number of missing parts. We used the fact that most scrolls are made from animal skins to "fingerprint" pieces based on DNA sequences. Genetic sorting of the scrolls illuminates their textual relationship and historical significance. Disambiguating the contested relationship between Jeremiah fragments supplies evidence that some scrolls were brought to the Qumran caves from elsewhere; significantly, they demonstrate that divergent versions of Jeremiah circulated in parallel throughout Israel (ancient Judea). Similarly, patterns discovered in non-biblical scrolls, particularly the Songs of the Sabbath Sacrifice, suggest that the Qumran scrolls represent the broader cultural milieu of the period. Finally, genetic analysis divorces debated fragments from the Qumran scrolls. Our study demonstrates that interdisciplinary approaches enrich the scholar's toolkit.
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Full text: 1 Database: MEDLINE Main subject: Skin / Base Sequence / Genetics Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: Israel

Full text: 1 Database: MEDLINE Main subject: Skin / Base Sequence / Genetics Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Cell Year: 2020 Type: Article Affiliation country: Israel