Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
Lancet Oncol
; 21(6): e330-e336, 2020 06.
Article
in En
| MEDLINE
| ID: mdl-32502459
ABSTRACT
Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Response should be assessed using MRI of brain and spine, neurological examination, and anti-inflammatory or antiangiogenic drugs. Clinical imaging standards are defined. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.
Full text:
1
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Brain Stem Neoplasms
/
Endpoint Determination
/
Neuroimaging
/
Diffuse Intrinsic Pontine Glioma
Type of study:
Guideline
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Lancet Oncol
Journal subject:
NEOPLASIAS
Year:
2020
Type:
Article
Affiliation country:
United States