Heterogeneity of cancer-associated fibroblasts: Opportunities for precision medicine.

Kanzaki, Ryu; Pietras, Kristian

Kanzaki, Ryu; Pietras, Kristian.

Affiliation

Kanzaki R; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University Cancer Centre, Lund University, Lund, Sweden.
Pietras K; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University Cancer Centre, Lund University, Lund, Sweden.

Cancer Sci ; 111(8): 2708-2717, 2020 Aug.

Article in En | MEDLINE | ID: mdl-32573845

Subject(s)

Antineoplastic Agents/pharmacology; Cancer-Associated Fibroblasts/drug effects; Neoplasms/drug therapy; Precision Medicine/methods; Tumor Microenvironment/genetics; Antineoplastic Agents/therapeutic use; Cancer-Associated Fibroblasts/metabolism; Disease Progression; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; Gene Expression Regulation, Neoplastic/drug effects; Genetic Heterogeneity; Humans; Neoplasms/genetics; Neoplasms/pathology; RNA-Seq; Single-Cell Analysis; Tumor Microenvironment/drug effects

Key words

cancer progression; cancer-associated fibroblast; heterogeneity; single-cell RNA-sequencing; tumor microenvironment

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Full text: 1 Database: MEDLINE Main subject: Precision Medicine / Tumor Microenvironment / Cancer-Associated Fibroblasts / Neoplasms / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Cancer Sci Year: 2020 Type: Article Affiliation country: Sweden

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