Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
Genes Dev
; 34(15-16): 1033-1038, 2020 08 01.
Article
in En
| MEDLINE
| ID: mdl-32675325
ABSTRACT
Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral resources. The mechanisms that import Kyn into the nervous system are poorly understood. Here, we provide genetic, anatomical, biochemical, and behavioral evidence showing that in C. elegans an ortholog of the human LAT1 transporter, AAT-1, imports Kyn into sites of KynA production.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Caenorhabditis elegans
/
Large Neutral Amino Acid-Transporter 1
/
Caenorhabditis elegans Proteins
/
Kynurenic Acid
/
Neurons
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
2020
Type:
Article
Affiliation country:
United States