The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma.

Gan, Chao; Pierscianek, Daniela; El Hindy, Nicolai; Ahmadipour, Yahya; Keyvani, Kathy; Sure, Ulrich; Zhu, Yuan

Gan, Chao; Pierscianek, Daniela; El Hindy, Nicolai; Ahmadipour, Yahya; Keyvani, Kathy; Sure, Ulrich; Zhu, Yuan.

Affiliation

Gan C; Department of Neurosurgery and Spine Surgery, University hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Pierscianek D; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
El Hindy N; Department of Neurosurgery and Spine Surgery, University hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Ahmadipour Y; Department of Neurosurgery and Spine Surgery, University hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Keyvani K; Present Address: Department of Spine- and Peripheral Nerve-Surgery, St. Christophorus 625 Hospital, Werne, Germany.
Sure U; Department of Neurosurgery and Spine Surgery, University hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Zhu Y; Institute of Neuropathology, University hospital Essen, University of Duisburg-Essen, Essen, Germany.

BMC Cancer ; 20(1): 672, 2020 Jul 17.

Article in En | MEDLINE | ID: mdl-32680476

Subject(s)

Aldehyde Oxidoreductases/metabolism; Biomarkers, Tumor/metabolism; Brain Neoplasms/mortality; Glioblastoma/mortality; Neoplastic Stem Cells/metabolism; Aged; Aldehyde Oxidoreductases/analysis; Biomarkers, Tumor/analysis; Brain/pathology; Brain/surgery; Brain Neoplasms/pathology; Brain Neoplasms/surgery; Case-Control Studies; DNA Methylation; DNA Modification Methylases/genetics; DNA Repair Enzymes/genetics; Female; Gene Expression Regulation, Neoplastic; Glioblastoma/pathology; Glioblastoma/surgery; Humans; Male; Middle Aged; Neurosurgical Procedures; Prognosis; Promoter Regions, Genetic/genetics; Tumor Suppressor Proteins/genetics; Up-Regulation

Key words

ALDH1A3; Cancer stem cell marker; Overall survival; Peritumoral edema; Primary glioblastoma

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Brain Neoplasms / Biomarkers, Tumor / Glioblastoma / Aldehyde Oxidoreductases Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2020 Type: Article Affiliation country: Germany

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