Opioid-Free Anesthesia for Lung Cancer Resection: A Case-Control Study.
J Cardiothorac Vasc Anesth
; 34(11): 3036-3040, 2020 Nov.
Article
in En
| MEDLINE
| ID: mdl-32682739
ABSTRACT
OBJECTIVE:
To assess the feasibility and effectiveness of an opioid-free anesthesia (OFA) technique in lung cancer resection surgery versus standard opioid-based techniques.DESIGN:
Retrospective, propensity-matched, case-control study.SETTING:
A single, specialty cardiothoracic center between January 2018 and July 2019.PARTICIPANTS:
Adult patients undergoing lung cancer resection surgery.INTERVENTIONS:
A cohort of 83 patients undergoing an OFA technique (OFA group) for lung cancer resection surgery was matched with 83 patients who underwent similar surgery with a standard anesthesia technique (STD group). Outcome measures compared between the 2 groups included postoperative pain scores at 0, 1, and 24 hours; 24-hour postoperative morphine patient-controlled analgesia consumption; recovery room and hospital lengths of stay; and 30-day all-cause mortality. MEASUREMENT AND MAINRESULTS:
No difference was found in median pain scores (interquartile range [IQR]) at 0 hours STD 0 (0-1), OFA 0 (0-1); pâ¯=â¯0.48. Median pain scores (IQR) at 1 hour were statistically significantly greater in the STD group compared with the OFA group STD 1 (0-1), OFA 0 (0-1); pâ¯=â¯0.03. There was no difference in median pain scores (IQR) at 24 hours STD 0 (0-1), OFA 0 (0-1); pâ¯=â¯0.49. Mean postoperative 24-hour patient-controlled analgesia morphine consumption (standard deviation) was similar between groups STD 21.1 (±18.8) mg, OFA 16.2 (±18.1) mg; pâ¯=â¯0.16. There was no difference in mean time spent in the postoperative recovery (standard deviation) area between the 2 groups STD 116 (±49) minutes, OFA 108 (±34) minutes; pâ¯=â¯0.27. Median hospital length of stay (IQR) was longer in the STD group compared with the OFA group STD 4 (2-6) days, OFA 3 (2-4) days; pâ¯=â¯0.002.CONCLUSIONS:
This case-control study demonstrated that an OFA technique in lung cancer resection surgery offers a feasible and safe approach, resulting in similar postoperative pain scores and morphine consumption compared with standard opioid-containing techniques.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Anesthesia
/
Lung Neoplasms
Type of study:
Observational_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
J Cardiothorac Vasc Anesth
Journal subject:
ANESTESIOLOGIA
/
CARDIOLOGIA
Year:
2020
Type:
Article