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A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.
Shapiro, Geoffrey I; LoRusso, Patricia; Cho, Daniel C; Musib, Luna; Yan, Yibing; Wongchenko, Matthew; Chang, Ilsung; Patel, Premal; Chan, Iris T; Sanabria-Bohorquez, Sandra; Meng, Raymond D; Bendell, Johanna C.
Affiliation
  • Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. geoffrey_shapiro@dfci.harvard.edu.
  • LoRusso P; Yale Cancer Center, New Haven, CT, USA.
  • Cho DC; Perlmutter Cancer Center at NYU Langone Medical Center, New York, NY, USA.
  • Musib L; Genentech, Inc., South San Francisco, CA, USA.
  • Yan Y; Genentech, Inc., South San Francisco, CA, USA.
  • Wongchenko M; Genentech, Inc., South San Francisco, CA, USA.
  • Chang I; Genentech, Inc., South San Francisco, CA, USA.
  • Patel P; Celltrion, Inc., Incheon, South Korea.
  • Chan IT; Genentech, Inc., South San Francisco, CA, USA.
  • Sanabria-Bohorquez S; Genentech, Inc., South San Francisco, CA, USA.
  • Meng RD; Genentech, Inc., South San Francisco, CA, USA.
  • Bendell JC; Genentech, Inc., South San Francisco, CA, USA.
Invest New Drugs ; 39(1): 163-174, 2021 02.
Article in En | MEDLINE | ID: mdl-32737717
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Piperidines / Pyrimidines / Azetidines / Antineoplastic Agents Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Piperazines / Piperidines / Pyrimidines / Azetidines / Antineoplastic Agents Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Type: Article Affiliation country: United States