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Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.
Nagumo, Yasuyuki; Katoh, Koki; Iio, Keita; Saitoh, Tsuyoshi; Kutsumura, Noriki; Yamamoto, Naoshi; Ishikawa, Yukiko; Irukayama-Tomobe, Yoko; Ogawa, Yasuhiro; Baba, Takeshi; Tanimura, Ryuji; Yanagisawa, Masashi; Nagase, Hiroshi.
Affiliation
  • Nagumo Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Katoh K; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8571, Japan.
  • Iio K; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8571, Japan.
  • Saitoh T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Kutsumura N; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8571, Japan.
  • Yamamoto N; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Ishikawa Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Irukayama-Tomobe Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Ogawa Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan.
  • Baba T; Pharmaceutical Research Laboratories, Toray Industry Inc, 10-1, Tebiro 6-choume, Kamakura, Kanagawa 248 8555, Japan.
  • Tanimura R; Pharmaceutical Research Laboratories, Toray Industry Inc, 10-1, Tebiro 6-choume, Kamakura, Kanagawa 248 8555, Japan.
  • Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan; R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan; Department of
  • Nagase H; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305 8571, Japan. Electronic address: nagase.hiroshi.gt@u.t
Bioorg Med Chem Lett ; 30(17): 127360, 2020 09 01.
Article in En | MEDLINE | ID: mdl-32738987
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Full text: 1 Database: MEDLINE Main subject: Spiro Compounds / Orexin Receptors / Orexin Receptor Antagonists / Morphinans Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: Japan
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Spiro Compounds / Orexin Receptors / Orexin Receptor Antagonists / Morphinans Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Type: Article Affiliation country: Japan