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Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients.
Bellon, Mathilde; Schweblin, Cecilia; Lambeng, Nathalie; Cherpillod, Pascal; Vazquez, Jessica; Lalive, Patrice H; Schibler, Manuel; Deffert, Christine.
Affiliation
  • Bellon M; Laboratory of Virology, Laboratory Medicine Division, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.
  • Schweblin C; Division of Infectious Disease, Department of Medical Specialties, Geneva University Hospitals, Geneva, Switzerland.
  • Lambeng N; Faculty of Medicine of Geneva, University of Geneva, Geneva, Switzerland.
  • Cherpillod P; Laboratory of Virology, Laboratory Medicine Division, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.
  • Vazquez J; Division of Infectious Disease, Department of Medical Specialties, Geneva University Hospitals, Geneva, Switzerland.
  • Lalive PH; Faculty of Medicine of Geneva, University of Geneva, Geneva, Switzerland.
  • Schibler M; Laboratory of Biological Fluids, Laboratory Medicine Division, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.
  • Deffert C; Laboratory of Virology, Laboratory Medicine Division, Diagnostic Department, Geneva University Hospitals, Geneva, Switzerland.
Clin Infect Dis ; 73(9): e3102-e3105, 2021 11 02.
Article in En | MEDLINE | ID: mdl-32770235
This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
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Full text: 1 Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2021 Type: Article Affiliation country: Switzerland
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Full text: 1 Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2021 Type: Article Affiliation country: Switzerland